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Penile Injection Therapy - Urology Centers of Alabama | Urology Centers of Alabama

Polyamines have a widely recognized dual role: they stabilise macromolecules at low concentrations, modulate signalling and protect against stress, whereas they can actively trigger or potentiate PCD at higher concentrations

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Non-immunogenic forms of cell death (e.g., apoptosis) are immunologically silent, whereas ICD transforms dying tumor cells into endogenous “tumor vaccines” through the release of DAMPs—including CRT exposed on the cell surface, HMGB1, and ATP—thereby effectively activating dendritic cells (DCs) and initiating antigen-specific T-cell responses (52)